A Study of CD8+ T Cell Imaging During Treatment in People With Non-Small Cell Lung Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06863233
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Zirconium Zr 89 crefmirlimab berdoxam — DRUG
    Zirconium Zr 89 crefmirlimab berdoxam, the investigational agent proposed in this imaging study, is an anti-CD8 minibody (crefmirlimab), conjugated with deferoxamine (Df, berdoxam) and radiolabeled with Zirconium-89.
  • PET/CT Scan — DIAGNOSTIC_TEST
    Each patient will undergo up to four infusions of Zirconium Zr 89 crefmirlimab berdoxam followed by PET/CT 24 hours later (+/- 3 hours).

Study Details

The purpose of this study to learn whether PET/CT (positron emission tomography/computed tomography) scans using an imaging agent (radiotracer) called zirconium Zr 89 crefmirlimab berdoxam is a safe and effective way to identify CD8+ T cells

Key Dates

Start date
Mar 3, 2025
Status verified
Aug 2025
Primary completion
Mar 3, 2028
Completion
Mar 3, 2028

Study Design

Enrollment
5 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Participants with Metastatic non-small cell lung cancer (NSCLC)
    Participants will have a diagnosis of metastatic non-small cell lung cancer (NSCLC)

Primary Outcome Measure

Difference between Zirconium Zr 89 crefmirlimab berdoxam PET uptake at pre- vs post-TIL infusion and pre- vs post-ACZ redosing. [ Time Frame: Baseline to two weeks ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Consent Only)Basking RidgeNew Jersey07920
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Monmouth (Consent Only)MiddletownNew Jersey07748
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Bergen (Consent Only)MontvaleNew Jersey07645
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only)CommackNew York11725
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Westchester (Consent only)HarrisonNew York10604
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Cancer Center (All protocol activities)New YorkNew York10065
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Cancer Center @ Nassau (Consent only)UniondaleNew York11553
Adam Schoenfeld, MD
646-608-4042

Find similar trials in Basking Ridge, NJ

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Memorial Sloan Kettering at Basking Ridge (Consent Only)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Consent Only)· Middletown, NJMemorial Sloan Kettering Bergen (Consent Only)· Montvale, NJMemorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only)· Commack, NYMemorial Sloan Kettering Westchester (Consent only)· Harrison, NYMemorial Sloan Kettering Cancer Center (All protocol activities)· New York, NY

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