Effects of Beverage Volume, Glycerol Concentration, and Sodium Concentration on Fluid Balance in Healthy Euhydrated Men and Women at Rest

Conditions

• Fluid Balance

Eligibility Criteria

Sex

ALL

Age

18 Years - 50 Years

Healthy Volunteers

Accepted

Interventions

• Placebo beverage, kiwi-strawberry flavor — OTHER
  9.3.oz 3 times for a total of 28 oz over a 35 min period followed by 25 min rest until Time 0 post-dose
• Electrolyte solution without glycerol beverage 1 — OTHER
  4 oz 3 times for a total of 12 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Electrolyte solution without glycerol beverage 2 — OTHER
  6.7 oz 3 times for a total of 20 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Electrolyte solution without glycerol beverage 3 — OTHER
  9.3.oz 3 times for a total of 28 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Electrolyte solution with glycerol beverage 1 — OTHER
  4 oz 3 times for a total of 12 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Electrolyte solution with glycerol beverage 2 — OTHER
  4 oz 3 times for a total of 12 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Electrolyte solution with glycerol beverage 3 — OTHER
  9.3.oz 3 times for a total of 28 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Base with glycerol, no electrolytes beverage 1 — OTHER
  4 oz 3 times for a total of 12 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Base with glycerol, no electrolytes beverage 2 — OTHER
  6.7 oz 3 times for a total of 20 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.
• Base with glycerol, no electrolytes beverage 3 — OTHER
  9.3.oz 3 times for a total of 28 oz over a 35 min period followed by 25 min rest until Time 0 post-dose. Beverage matched to placebo for color and flavor.

Study Details

The presence of certain ingredients such as sodium and glycerol can facilitate retention of the fluid consumed via renal water reabsorption. To maintain overall whole-body fluid balance, it is important that ingested fluid is retained in the body instead of losing it through urination. The purpose of this study is to determine the effect of sodium and glycerol concentrations at various fluid intake volumes on fluid balance in healthy, euhydrated men and women.

Key Dates

Start date

Apr 9, 2025

Status verified

Jul 2025

Primary completion

Dec 15, 2025

Completion

Dec 15, 2025

Study Design

Enrollment

80 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Arms

• Placebo Comparator: Placebo beverage
  Base beverage, no electrolytes, no glycerol
• Experimental: Electrolyte solution without glycerol beverage 1
  Higher electrolytes lower volume
• Experimental: Electrolyte solution without glycerol beverage 2
  Lower electrolytes mid-volume
• Experimental: Electrolyte solution without glycerol beverage 3
  Higher electrolytes higher volume
• Experimental: Electrolyte solution with glycerol beverage 1
  Lower electrolytes, lower glycerol, lower volume
• Experimental: Electrolyte solution with glycerol beverage 2
  Higher electrolytes, higher glycerol, lower volume
• Experimental: Electrolyte solution with glycerol beverage 3
  Higher electrolytes, higher glycerol, higher volume
• Experimental: Base with glycerol beverage 1
  No electrolytes, higher glycerol, lower volume
• Experimental: Base with glycerol beverage 2
  No electrolytes, lower glycerol, mid-volume
• Experimental: Base with glycerol beverage 3
  No electrolytes, higher glycerol, higher volume

Primary Outcome Measure

Fluid balance [ Time Frame: Change from baseline (pre-beverage) to post-beverage Time 30, 60, 90,120, 150,180 and 210 minutes ]

Central Contacts

• Lindsay Baker, PhD
  800.884.2867
  [email protected]

Locations (3)

Find similar trials in Bradenton, FL

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