Effects of Ultra Processed Food on Intestinal Energy Harvest

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT06853288
Status
Recruiting
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Conditions

  • Obesity and Overweight

Eligibility Criteria

Sex
ALL
Age
25 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Diet containing 80% ultra processed foods — BEHAVIORAL
    Very high ultra-processed food diet where 80% of calories are coming from ultra processed food
  • Diet containing 20% ultra processed foods — BEHAVIORAL
    Low ultra processed food diet where 20% of the calories are coming from ultra processed food

Study Details

Ultra processed food is everywhere in modern society and may contain multiple ingredients that affect the way participants' bodies store energy. Some studies have shown that eating a diet high in ultra processed foods leads to weight gain, but these foods have not been studied enough to understand why. Recently, the gut microbiome has become a potential way to measure energy balance in the human body; this is done by measuring how many calories are in the stool. The investigators propose to test a very high ultra-processed food diet where 80% of calories are coming from ultra processed food and a low ultra processed food diet where 20% of the calories are coming from ultra processed food. This study will compare stool sample energy content of the two diets.

Key Dates

Start date
Mar 30, 2025
Status verified
Sep 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: 80% Ultra processed
    Participants will be provided with shopping lists and menus for the two arms of the diet intervention.
  • Experimental: 20% Ultra processed
    Participants will be provided with shopping lists and menus for the two arms of the diet intervention.

Primary Outcome Measure

Fecal energy loss [ Time Frame: 2 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Faris M Zuraikat, PhD
Faris M Zuraikat, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Columbia University Irving Medical Center· New York, NY

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