The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
AO Foundation, AO Spine
Study ID
NCT06839300
Status
Recruiting
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Conditions

  • Spinal Cord Injury

Eligibility Criteria

Sex
ALL
Age
19 Years - N/A
Healthy Volunteers
Not accepted

Study Details

To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.

Key Dates

Start date
Feb 9, 2026
Status verified
May 2026
Primary completion
Dec 1, 2029
Completion
Dec 1, 2029

Study Design

Enrollment
260 participants (estimated)

Arms

  • Arm: SCI patients
    Patients with traumatic SCI
  • Arm: Non-SCI patients (control group)
    Non-SCI spine trauma control participants

Primary Outcome Measure

Accuracy of serum NF-L and GFAP biomarkers postinjury for predicting the severity of neurologic imapairement at 6 months postinjury as either motor complete or motor incomplete. [ Time Frame: 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical College of WisconsinMilwaukeeWisconsin53226
Aditya Vedantam
[email protected]

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By research site
Medical College of Wisconsin· Milwaukee, WI

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