Biomarkers for Cognitive Decline in Intracerebral Hemorrhage

Conditions

• Primary Intracerebral Hemorrhage

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Not accepted

Interventions

• MRI — DIAGNOSTIC_TEST
  MRI during hospitalization and at 12 months post sICH
• Blood Draw — DIAGNOSTIC_TEST
  Will occur during hospitalization and at 3, 6 and 12 months post sICH
• Cognitive Test — DIAGNOSTIC_TEST
  Cognitive testing will occur during hospitalization and at 3, 6 and 12 months post sICH

Study Details

The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous intracerebral hemorrhage (sICH), or blood clot in the brain. The main questions it aims to answer are * if SBIs in sICH are associated with a lower cognitive level and more rapid cognitive decline * if SBIs in sICH are associated with certain findings on brain imaging * if SBIs in sICH are associated with higher inflammation measured by certain blood tests Participants will undergo * cognitive testing during hospitalization, and at 3, 6 and 12 months after the sICH * Magnetic Resonance Imaging (MRI) of the brain during hospitalization and 12 months after the sICH * blood draws during hospitalization and at 3, 6 and 12 months after the sICH

Key Dates

Start date

Aug 2, 2025

Status verified

Aug 2025

Primary completion

Aug 1, 2029

Completion

Aug 1, 2029

Study Design

Enrollment

118 participants (estimated)

Primary Outcome Measure

Global Cognition [ Time Frame: From date of randomization and assessed throughout the during hospitalization for qualifying ICH event up to 12 months ]

Central Contacts

• Amanda Sremac, BS
  312-942-0593
  [email protected]
• Rajeev Garg, MD
  [email protected]

Locations (1)

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