IPV and Lung Compliance in Invasively Ventilated Children

Part of paid clinical trials in New Hyde Park, New York.

Sponsor
Northwell Health
Study ID
NCT06836050
Status
Recruiting
Apply to this trial

Conditions

  • Lung Compliance
  • Pediatric Acute Respiratory Distress Syndrome (PARDS)
  • Pediatric Respiratory Diseases

Eligibility Criteria

Sex
ALL
Age
0 Days - 18 Years
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation. The main questions it aims to answer are: 1. Does IPV improve lung compliance 15 minutes after and 3 hours after receiving one treatment in a heterogeneous group of pediatric patients? 2. Does IPV improve lung compliance in patients with Pediatric Acute Respiratory Distress Syndrome (PARDS), and what is the degree of change compared to those without PARDS? 3. What is the effect of IPV on lung compliance according to PARDS severity (mild-moderate disease vs. severe disease). 4. What is the incidence of adverse effects of IPV? Participants will receive IPV because their medical team feels it will help their lung recovery and has already determined them to be safe candidates to receive this therapy, which is a standard airway clearance modality already routinely used in our PICU. Nothing additional will happen to participants as a result of this study. Enrolling in this study simply gives the study team permission to collect specific health information that identifies your child for research purposes, which may include results from medical tests found in their medical record and information from your child's bedside monitor and ventilator. This information will be collected before and after the IPV treatments to evaluate their response to the therapy.

Key Dates

Start date
Jan 13, 2025
Status verified
Feb 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
30 participants (estimated)

Primary Outcome Measure

Dynamic Compliance [ Time Frame: Baseline (15 minutes before IPV treatment), 15 minutes after IPV treatment, and 3 hours after IPV treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cohen Children's Medical CenterNew Hyde ParkNew York11040
Alexandra B Cummings, DO
[email protected]
631-223-6032
Alexandra B Cummings, DO (SUB_INVESTIGATOR)
Todd Sweberg, MD (PRINCIPAL_INVESTIGATOR)
Layne Silveer, MD (SUB_INVESTIGATOR)

Find similar trials in New Hyde Park, NY

By research site
Cohen Children's Medical Center· New Hyde Park, NY

Related Studies