Neuroimaging of Escitalopram in Autism Spectrum Disorder

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
Kathryn Unruh
Study ID
NCT06826326
Phase
PHASE2
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
12 Years - 17 Years
Healthy Volunteers
Not accepted

Interventions

  • Escitalopram 10mg — DRUG
    oral administration of escitalopram 10 mg
  • Placebo — DRUG
    Placebo

Study Details

The goal of this clinical trial is to evaluate the acute effects of escitalopram (Lexapro®) on select brain networks during task-based functional magnetic resonance imaging (fMRI) in adolescent individuals with autism spectrum disorder (ASD). We hope to learn more about the acute effects of escitalopram and how it might be used to treat inflexible thinking or rigid-compulsive behavior that can be associated with restricted and repetitive behaviors in adolescents with ASD. Participants will: * Attend 3 visits to complete tests of thinking abilities and fill out surveys about their health and behavior * Be randomly assigned to receive escitalopram at one of the first two visits after screening and a placebo at the other visit. * Complete a reward-based task that tracks eye movement, either during MRI or in laboratory environment.

Key Dates

Start date
Apr 28, 2025
Status verified
Feb 2026
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
5 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Escitalopram then Placebo
    participants will receive escitalopram during visit 2 and placebo during visit 3
  • Experimental: Placebo then Escitalopram
    participant will receive placebo during visit 2 and escitalopram during visit 3

Primary Outcome Measure

Rewarded Antisaccade task [ Time Frame: At Visit 2 (1 day to 1 month after Screening/Visit 1) and Visit 3 (5 days to 3 weeks after Visit 2) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Hoglund Biomedical Imaging CenterKansas CityKansas66103-

Find similar trials in Kansas City, KS

By condition
Autism spectrum disorder
By specialty
Pediatrics
By research site
Hoglund Biomedical Imaging Center· Kansas City, KS

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