Adaptive Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease

Part of paid clinical trials in San Francisco, California.

Sponsor
Doris Wang, MD, PhD
Study ID
NCT06819020
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Percept RC — DEVICE
    Using the Percept RC pulse generator, patients receive clinically-optimized open loop stimulation to the pallidum/subthalmaic nucleus.
  • Percept RC — DEVICE
    Using the Percept RC pulse generator, patients receive increased adaptive stimulation to the pallidum/subthalmaic nucleus.
  • Percept RC — DEVICE
    Using the Percept RC pulse generator, patients receive decreased adaptive stimulation to the pallidum/subthalmaic nucleus.

Study Details

The goal of this clinical trial is to learn if adaptive deep brain stimulation (DBS) can decrease or prevent freezing of gait in participants with Parkinson's disease.

Key Dates

Start date
Jan 31, 2026
Status verified
Oct 2025
Primary completion
Aug 1, 2029
Completion
Aug 1, 2029

Study Design

Enrollment
20 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Open-loop deep brain stimulation
    Participants with Parkinson's disease implanted with Percept RC and brain lead implanted in the pallidal/striatal region receiving open-loop deep brain stimulation.
  • Active Comparator: Adaptive deep brain stimulation (ramp-up)
    Participants with Parkinson's disease implanted with Percept RC and brain lead implanted in the pallidal/striatal region receiving increased stimulation in-response to gait-behavior biomarker.
  • Active Comparator: Adaptive deep brain stimulation (ramp-down)
    Participants with Parkinson's disease implanted with Percept RC and brain lead implanted in the pallidal/striatal region receiving decreased stimulation in-response to gait-behavior biomarker.

Primary Outcome Measure

Freezing of gait [ Time Frame: Baseline and 2 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San FranciscoSan FranciscoCalifornia94143-

Find similar trials in San Francisco, CA

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
University of California, San Francisco· San Francisco, CA

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