Effects of Ketone Supplement and Alcohol on Brain Metabolism

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT06815237
Phase
PHASE2/PHASE3
Status
Recruiting
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Conditions

  • Alcohol Drinking
  • Ketosis
  • MRI

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Kenetik — DIETARY_SUPPLEMENT
    Ketone supplement is randomly given once.
  • Alcohol beverage — OTHER
    Alcohol beverage is randomly given once. Participants will receive the alcohol beverage that dose-adjusts for body weight and sex differences in pharmacokinetics and calculated to obtain a final breath alcohol concentration of 0.050%

Study Details

The research study is being conducted to better understand the effects of ketones and alcohol on brain functioning and brain metabolism. Participants will be asked to undergo three identical MRI visits after three single-dose interventions: (1) drink a ketone supplement drink, (2) drink an alcoholic beverage, (3) no intervention. These interventions will be randomly assigned (meaning everyone receives all 3 interventions, but in different orders).

Key Dates

Start date
May 13, 2025
Status verified
Mar 2026
Primary completion
May 31, 2029
Completion
May 31, 2029

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Ketone Supplement
    Subjects will receive ketone supplement once by mouth, 20g of kentones.
  • Experimental: Alcohol beverage
    Alcohol lab, participants will receive ethanol drinks that are dose-adjusted for body weight and sex differences in pharmacokinetics and calculated to obtain a final breath alcohol concentration of 0.050%
  • No Intervention: No Intervention
    No intervention will be given

Primary Outcome Measure

To examine the acute effects of ketone supplements compared to no intervention on Nicotinamide adenine dinucleotide levels in the brain. [ Time Frame: 60 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Studies of AddictionPhiladelphiaPennsylvania19104
Timothy Pond, MPH
[email protected]
215-746-1959
Corinde Wiers, Ph.D (PRINCIPAL_INVESTIGATOR)
Cindy Li, Ph.D. (SUB_INVESTIGATOR)

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By research site
Center for Studies of Addiction· Philadelphia, PA

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