A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease

Part of paid clinical trials in Los Alamitos, California.

Sponsor
Eli Lilly and Company
Study ID
NCT06809400
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
30 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • LY4006896 — DRUG
    Administered intravenously (IV)
  • Placebo — DRUG
    Administered IV

Study Details

The purpose of this study is to generate evidence of the safety, tolerability, and pharmacokinetics/pharmacodynamics of IV LY4006896 compared with placebo in healthy participants and participants with Parkinson's disease.

Key Dates

Start date
Feb 18, 2025
Status verified
Apr 2026
Primary completion
Jan 31, 2028
Completion
Jan 31, 2028

Study Design

Enrollment
127 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Part A LY4006896 + Placebo
    Healthy participants will receive a single escalating dose of LY4006896 and matching placebo.
  • Experimental: Part B LY4006896 + Placebo
    Participants with Parkinson's disease will receive multiple escalating doses of LY4006896 and matching placebo.

Primary Outcome Measure

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Part A [ Time Frame: Baseline to Week 48 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (12)

FacilityCityStateZIPSite coordinators
Collaborative Neuroscience Network - CNSLos AlamitosCalifornia90720
844-424-9494
Steven Reynolds (PRINCIPAL_INVESTIGATOR)
Collaborative Neuroscience Network - CNSLos AlamitosCalifornia90720
562-742-7116
Omid Omidvar (PRINCIPAL_INVESTIGATOR)
K2 Medical Research, LLCMaitlandFlorida32751-
Aqualane Clinical ResearchNaplesFlorida34105
239-529-6780
William Justiz (PRINCIPAL_INVESTIGATOR)
Charter ResearchOrlandoFlorida32803
407-337-1000
Diana Balsalobre (PRINCIPAL_INVESTIGATOR)
Progressive Medical ResearchPort OrangeFlorida32127
386-304-7070
Alexander White (PRINCIPAL_INVESTIGATOR)
Charter ResearchThe VillagesFlorida32162-2698
352-775-1000
Jeffrey Norton (PRINCIPAL_INVESTIGATOR)
K2 Medical Research, LLCThe VillagesFlorida32159
321-278-5590
Craig Curtis (PRINCIPAL_INVESTIGATOR)
QUEST Research InstituteFarmington HillsMichigan48334
248-957-8940
Aaron Ellenbogen (PRINCIPAL_INVESTIGATOR)
PPD Development, LPAustinTexas78744
877-773-3707
Sabrina Merchant (PRINCIPAL_INVESTIGATOR)
Evergreen Health ResearchKirklandWashington98034
425-899-5385
Pinky Agarwal (PRINCIPAL_INVESTIGATOR)
Inland Northwest ResearchSpokaneWashington99202
509-960-2818
Jason Aldred (PRINCIPAL_INVESTIGATOR)

Find similar trials in Los Alamitos, CA

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Collaborative Neuroscience Network - CNS· Los Alamitos, CAK2 Medical Research, LLC· Maitland, FLAqualane Clinical Research· Naples, FLCharter Research· Orlando, FLProgressive Medical Research· Port Orange, FLCharter Research· The Villages, FL

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