Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Part of paid clinical trials in Miami, Florida.

Sponsor
University of Miami
Study ID
NCT06807866
Phase
PHASE4
Status
Recruiting
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Conditions

  • THA

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Duloxetine — DRUG
    Participants will come in person and receive a one time 60 mg dose by mouth.
  • Placebo — OTHER
    Participants will come in person and receive a one time 60 mg placebo pill dose by mouth.

Study Details

The primary objective of this study is to compare total narcotic intake standardized via milligram morphine equivalents between duloxetine and placebo cohorts after a total hip arthroplasty.

Key Dates

Start date
Mar 1, 2025
Status verified
Mar 2026
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
64 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Duloxetine group
    Participants will be in this group for up to 2 hours.
  • Placebo Comparator: Placebo group
    Participants will be in this group for up to 2 hours.

Primary Outcome Measure

Total Milligram Morphine Equivalent (MME) [ Time Frame: Up to 24 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MiamiMiamiFlorida33136
Natalia Cruz, MD
[email protected]
3056895195
Ryan Hellinger, BA
[email protected]
3056895195
Victor H Hernandez, MD (PRINCIPAL_INVESTIGATOR)
Natalia Cruz, MD (SUB_INVESTIGATOR)
Ryan Hellinger, BA (SUB_INVESTIGATOR)

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By research site
University of Miami· Miami, FL

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