Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT06807606
Phase
PHASE2
Status
Recruiting
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Conditions

  • Hematologic Malignancies

Eligibility Criteria

Sex
ALL
Age
N/A - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Drugs Cyclophosphamide — DRUG
    Given as standard of care treatment through IV infusion
  • Fludarabine — DRUG
    Given as standard of care treatment through IV infusion
  • Thiotepa — DRUG
    Given as standard of care treatment through IV infusion
  • Tacrolimus — DRUG
    Given as standard of care treatment through IV infusion
  • Mycophenolate mofetil — DRUG
    Given as standard of care treatment through IV infusion

Study Details

The goal of this clinical research study is to learn if intermediate-intensity conditioning therapy followed by a cord blood transplant can help to control high-risk hematological malignancies in patients who need a second allogeneic stem cell transplantation.

Key Dates

Start date
Mar 3, 2025
Status verified
Apr 2026
Primary completion
Nov 30, 2027
Completion
Nov 30, 2029

Study Design

Enrollment
35 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Optimized CBT
    Participants enrollment on trial will be determined by consultation with the physicians of the SCT Service.

Primary Outcome Measure

Safety and Adverse Events (AEs) [ Time Frame: Through study completion; an average of 1 year. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas M. D. Anderson Cancer CenterHoustonTexas77030
Warren Fingrut, MD
[email protected]
713-745-2214
Warren Fingrut, MD (PRINCIPAL_INVESTIGATOR)

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By research site
The University of Texas M. D. Anderson Cancer Center· Houston, TX

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