Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT06802276
Status
Recruiting
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Conditions

  • Gastrointestinal Microbiome
  • Hydrogen Sulfide

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • High Cysteine Diet — OTHER
    A healthy diet pattern which contains high levels of cysteine or cysteine-related compounds. The high and low cysteine diets will be designed by a research dietician to differ primarily in their concentration of cysteine while providing similar levels of calories, protein, fats, carbohydrates, fiber, and several micronutrients. No additional supplementation of cysteine will be used. Examples of high cysteine foods: chicken, eggs, lentils, yogurt, garlic, cheese, soybeans
  • Low Cysteine Diet — OTHER
    A healthy diet pattern which contains low levels of cysteine or cysteine-related compounds. The high and low cysteine diets will be designed by a research dietician to differ primarily in their concentration of cysteine while providing similar levels of calories, protein, fats, carbohydrates, fiber, and several micronutrients. The low cysteine diet includes lower-protein food sources. Examples of low cysteine foods: rice, bread, oranges, bananas, lettuce, snow peas, peppers

Study Details

The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.

Key Dates

Start date
May 21, 2025
Status verified
Apr 2026
Primary completion
Jun 1, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
25 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Active Comparator: High Cysteine Diet
    A dietary pattern designed to have a high level of dietary cysteine
  • Other: Low Cysteine Diet
    A dietary pattern designed to have a low level of dietary cysteine

Primary Outcome Measure

Hydrogen sulfide (H2S) [ Time Frame: Daily for 6 days during each dietary intervention period (total of 12 days). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado Anschutz Medical CampusAuroraColorado80045
Devin Grove, BS
[email protected]
303-724-1179

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By research site
University of Colorado Anschutz Medical Campus· Aurora, CO

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