Opioid Use Disorder and Pain

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT06800703
Status
Recruiting
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Conditions

  • Healthy Controls Group - Age and Sex-matched
  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • follow up interviews for 12 months to determine opioid use — BEHAVIORAL
    Follow-up

Study Details

The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse? Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use. Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.

Key Dates

Start date
Feb 4, 2025
Status verified
Feb 2025
Primary completion
Jan 31, 2028
Completion
Jan 31, 2028

Study Design

Enrollment
180 participants (estimated)

Arms

  • Arm: opioid use disorder
    individuals with OUD diagnosis
  • Arm: Healthy controls
    Healthy individuals without substance use disorders

Primary Outcome Measure

Avoidance learning measure [ Time Frame: Day 1 (immediately after consent and clinical assessment) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Connecticut Mental Health Center, S105New HavenConnecticut06519
Thang M Le, PhD
[email protected]
203-974-7360

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By research site
Connecticut Mental Health Center, S105· New Haven, CT

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