Neocortical Microarchitecture of Executive Function

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT06778135
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
45 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Temporary implatation of large-scale intracranial electrode. — PROCEDURE
    The Neuropixels probe (imec, Leuven, Belgium) is a new high resolution multi electrode technology that uses custom 130-nm complementary metal-oxide-semiconductor fabrication with high surface area but low-impedance titanium nitride recordings to produce high site count devices with extreme electrode density in a small package.
  • brain electrode — DEVICE
    Show that Neuropixels can safely and effectively record from large populations of neurons.

Study Details

This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.

Key Dates

Start date
Jul 25, 2025
Status verified
Sep 2025
Primary completion
Oct 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY

Arms

  • Experimental: Implanted

Primary Outcome Measure

Measure the neural population representations of task parameters along, and within, the cortical layers. [ Time Frame: 20 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of ColoradoAuroraColorado80045
Pamela David Gerecht, Ph.D.
[email protected]
303-724-4134
Daniel R Kramer, MD (PRINCIPAL_INVESTIGATOR)

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