Electrophysiological Representations of Odor in the Human Brain Study 1

Conditions

• Odor Intensity Ratings

Eligibility Criteria

Sex

ALL

Age

12 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• odor — BEHAVIORAL
  present odor

Study Details

Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.

Key Dates

Start date

Apr 1, 2024

Status verified

Jan 2025

Primary completion

Apr 1, 2026

Completion

Aug 1, 2028

Study Design

Enrollment

28 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Investigating representations of odor intensity in human piriform cortex.
  Odors will be presented at different concentrations.

Primary Outcome Measure

Perceived odor intensity [ Time Frame: 15 minutes ]

Central Contacts

• Naelly Arriaga, MPH
  312-503-7244
  [email protected]

Locations (1)

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