A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

Part of paid clinical trials in Buffalo, New York.

Sponsor
Roswell Park Cancer Institute
Study ID
NCT06733363
Phase
PHASE2
Status
Recruiting
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Conditions

  • Non-Muscle Invasive Bladder Carcinoma
  • Recurrent Bladder Carcinoma
  • Recurrent Non-Muscle Invasive Bladder Carcinoma
  • Stage 0a Bladder Cancer AJCC v8
  • Stage 1 Bladder Cancer AJCC v8

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Behavioral Dietary Intervention — BEHAVIORAL
    Participate in POW-R Health Only/Core program
  • Telephone- Based Intervention — BEHAVIORAL
    Receive live phone calls

Study Details

This phase II trial is being done to develop and test a healthy eating program to reduce cancer recurrence (cancer that has come back after a period of improvement) and/or progression (cancer that is growing, spreading, or getting worse) in patients with non-muscle invasive bladder cancer (NMIBC). Researchers want to better understand how incorporating more cruciferous vegetables in the diet may reduce the risk of cancer recurrence or progression in men and women who were diagnosed with early-stage bladder cancer and compare whether extending the program can further improve bladder cancer outcomes. POW-R Health is a behavioral dietary intervention designed to modestly increase cruciferous vegetable (cruciferae) intake in patients. Cruciferous vegetables, such as cabbage, kale and broccoli, arugula, contain phytochemicals known as isothiocyanates (ITCs). Dietary ITCs exert potent anticancer activities against bladder cancer and can be rapidly metabolized, delivered to the bladder, and concentrated in the urine. Participating in the healthy eating program may reduce bladder cancer recurrence or progression in NMIBC survivors.

Key Dates

Start date
Jan 13, 2026
Status verified
May 2026
Primary completion
Jan 13, 2028
Completion
Feb 28, 2029

Study Design

Enrollment
344 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Adaptation
    CAB members participate in maintenance phase development discussion over an hour up to 3 times per week.
  • Experimental: Arm II - POW-R Health Only/Core + Maintenance
    Patients receive study materials and phone calls during life of study

Primary Outcome Measure

Urinary isothiocyanates (ITCs) levels [ Time Frame: Baseline throughout life of study - up to 24 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Roswell Park Comprehensive Cancer CenterBuffaloNew York14263
Karen Yeary, MD
[email protected]
877-275-7724

Find similar trials in Buffalo, NY

By research site
Roswell Park Comprehensive Cancer Center· Buffalo, NY

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