How Many Dexamethasone Doses Should Be Given Perioperatively?

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06715709
Phase
PHASE4
Status
Enrolling By Invitation

Conditions

  • Arthropathy of Knee

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Dexamethasone IV — DRUG
    Patients will receive dexamethasone administered intraoperatively at the time of anesthesia. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus.
  • Dexamethasone IV+Oral — DRUG
    Patients will receive dexamethasone administered intraoperatively and on the morning of the first postoperative day. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus. The medication will be intravenously administered while inpatient, and via oral route when discharged.
  • Dexamethasone IV+Oral 2 Day — DRUG
    Patients will receive dexamethasone administered intraoperatively, the morning of the first postoperative day, and the morning of the second postoperative day. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus. The medication will be intravenously administered while inpatient, and via oral route when discharged.

Study Details

The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications

Key Dates

Start date
Mar 25, 2025
Status verified
Feb 2026
Primary completion
Jan 1, 2027
Completion
Jan 1, 2027

Study Design

Enrollment
339 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Other: (1) dexamethasone administered intraoperatively at the time of anesthesia
    (1) dexamethasone administered intraoperatively at the time of anesthesia
  • Experimental: (2) dexamethasone administered intraoperatively and on the morning of the first postoperative day,
    (2) dexamethasone administered intraoperatively and on the morning of the first postoperative day,
  • Experimental: (3) dexamethasone administered intraoperatively, the morning of the first& second postoperative day
    (3) dexamethasone administered intraoperatively, the morning of the first postoperative day, and the morning of the second postoperative day.

Primary Outcome Measure

Opioid consumption [ Time Frame: 72 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905-

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