ReadMap: Reading in Stroke Alexia and Typical Aging

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
Georgetown University
Study ID
NCT06700005
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups. Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

Key Dates

Start date
Jan 12, 2023
Status verified
Oct 2024
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Stroke Survivors
    Participants have had a left-hemisphere stroke, or a stroke elsewhere in the brain causing aphasia or alexia (i.e., reading difficulties). They are given a series of standardized and in-house tests of reading, language and cognition to provide a detailed profile of strengths and weaknesses, plus an MRI.
  • Arm: Controls
    Participants are matched to the stroke cohort in age, educational background, race, and gender but have no history of brain injury. They are also given a series of standardized and in-house tests of reading, language and cognition to provide a detailed profile of strengths and weaknesses, plus an MRI.

Primary Outcome Measure

MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo) [ Time Frame: Collected within 1 month of behavioral testing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Georgetown University Medical CenterWashington D.C.District of Columbia20057
Alycia Laks, MS, CCC-SLP
[email protected]
202-687-5205

Find similar trials in Washington D.C., DC

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Georgetown University Medical Center· Washington D.C., DC

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