Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Conditions

• Brain Activity Related to Drug Liking
• Brain Activity Related to Opioid Administration

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Observational study in patients receiving fentanyl for surgery — OTHER
  This observational study enrolls patients receiving fentanyl, a drug routinely administered during surgery under general anesthesia. The primary difference in the investigators' research protocol is the inclusion of a 5-minute interval between fentanyl administration and the induction of general anesthesia. Fentanyl will be given in two boluses of 2 mcg/kg (ideal body weight), spaced 2 minutes apart, totaling 4 mcg/kg. If the participant remains conscious, an additional 2 mcg/kg bolus will be administered after 2 minutes. Additionally, participants will complete a drug-liking questionnaire before the first bolus and every 30 seconds until anesthesia induction, rating how much they "liked" the drug on a 0-100 scale.

Study Details

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Key Dates

Start date

Feb 4, 2025

Status verified

Dec 2025

Primary completion

Dec 31, 2026

Completion

Dec 31, 2027

Study Design

Enrollment

20 participants (estimated)

Primary Outcome Measure

Source Localization of Fentanyl EEG Signature [ Time Frame: 15 minutes prior to surgery ]

Locations (1)

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