A Study of Cemiplimab and Fianlimab in People With Clear Cell Renal Cell Carcinoma

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06699602
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The researchers are doing this study to find out whether it is practical (feasible) to give cemiplimab and fianlimab before a nephrectomy and whether it causes any delays with surgery in people with kidney cancer. The researchers will also look at whether cemiplimab and fianlimab given before a nephrectomy is a safe and effective treatment approach and if there is a change in the size of the tumor following immunotherapy prior to planned surgery.

Key Dates

Start date
Feb 11, 2025
Status verified
Mar 2026
Primary completion
Feb 29, 2028
Completion
Feb 29, 2028

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Cemiplimab and Fianlimab
    All patients will be treated as follows: cemiplimab and fianlimab every 3 weeks for a total of 3 treatments, or until unacceptable toxic effects, overt disease progression, or withdrawal from study.

Primary Outcome Measure

response [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activites)Basking RidgeNew Jersey07920
Martin Voss, MD
646-888-4721
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Martin Voss, MD
646-888-4721
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Martin Voss, MD
646-888-4721
Memorial Sloan Kettering Cancer Center Suffolk - Commack (Limited Protocol Activities)CommackNew York11725
Martin Voss, MD
646-888-4721
Memorial Sloan Kettering West Harrison (Limited Protocol Activities)HarrisonNew York10604
Martin Voss, MD
646-888-4721
Memorial Sloan Kettering Cancer Center (All Protocol Activites)New YorkNew York10065
Martin Voss, MD
646-888-4721
Memorial Sloan Kettering Nassau (Limited Protocol Activities)UniondaleNew York11553
Martin Voss, MD
646-888-4721

Find similar trials in Basking Ridge, NJ

By condition
Kidney cancer
By specialty
OncologyUrology
By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activites)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Cancer Center Suffolk - Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering West Harrison (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activites)· New York, NY

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