A Randomized Controlled Trial of Oral CBD for the Treatment of Upper Extremity Musculoskeletal Pain

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
Brent DeGeorge
Study ID
NCT06695195
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Upper Extremity Bone Pain
  • Upper Extremity Muscle Pain
  • Upper Extremity Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cannabidiol (CBD) — DRUG
    25 mg capsule twice daily
  • Placebo — DRUG
    25 mg capsule twice daily

Study Details

The goal of this clinical trial is to learn about the use of cannabidiol (CBD) capsules as a treatment for musculoskeletal pain. CBD is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for hand and wrist osteoarthritis with topical CBD, however patients prefer oral CBD and no clinical trial has been performed to establish efficacy of oral CBD in humans for upper extremity musculoskeletal pain. The main questions it aims to answer are: Is CBD more effective than placebo at relieving pain for upper extremity musculoskeletal pain ? Is CBD safe for participants with upper extremity musculoskeletal pain? Participants will: take 4 weeks of daily CBD capsules take 4 weeks of daily placebo capsules answer surveys about how they are feeling and functioning. Participants will \[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\].

Key Dates

Start date
Jun 30, 2025
Status verified
Dec 2024
Primary completion
Mar 31, 2026
Completion
Mar 31, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Oral CBD
    Oral CBD 25 mg capsules taken twice each day for 4 weeks.
  • Placebo Comparator: Placebo
    Oral placebo capsules taken twice each day for 4 weeks

Primary Outcome Measure

Change from Baseline in Pain on the Visual Analog Pain (VAS) Score [ Time Frame: Baseline and Week 4, Week 6 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22903
Lindsey Wilkin, BS
[email protected]
571-225-8756
Brent DeGeorge, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Virginia· Charlottesville, VA

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