A Study to Assess the Effect of AZD0780 on Ambulatory Blood Pressure

Part of paid clinical trials in Inglewood, California.

Sponsor
AstraZeneca
Study ID
NCT06692764
Phase
PHASE2
Status
Completed

Conditions

  • Atherosclerotic Cardiovascular Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Placebo — DRUG
    0 mg (Placebo). Participants will receive three bottles, each containing 35 tablets with placebo tablets. Participants will take 1 tablet from each bottle on each scheduled day of study intervention, which will provide the placebo dose.
  • AZD0780 — DRUG
    Dose 1 Participants will receive three bottles, each containing 35 tablets: * 1 bottle of dose a AZD0780 tablets * 1 bottle of dose b AZD0780 tablets * 1 bottle of dose c AZD0780 tablets Participants will take 1 tablet from each bottle on each scheduled day of study intervention, which will provide the AZD0780 dose.

Study Details

This is a Phase II, multi-centre, randomized, double-blind, placebo-controlled, crossover study to evaluate the effect of AZD0780 Dose 1 versus placebo on systolic blood pressure (SBP) at Week 4, as measured by 24-hour ambulatory blood pressure monitoring (ABPM) in participants with ASCVD or risk equivalents and LDL-C ≥ 70 mg/dL, on stable medication.

Key Dates

Start date
Oct 30, 2024
Status verified
Feb 2026
Primary completion
Apr 18, 2025
Completion
May 2, 2025

Study Design

Enrollment
202 participants (actual)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: AZD0780
    Following randomization to treatment sequence, participants receive AZD0780 during period 1 or 2.
  • Placebo Comparator: Placebo
    Following randomization to treatment sequence, participants receive Placebo during period 1 or 2.

Primary Outcome Measure

To assess the effect of treatment with AZD0780 dose 1 versus placebo on ambulatory 24-hour average SBP at Week 4 [ Time Frame: Week 4 ]

Locations (26)

FacilityCityStateZIPSite coordinators
Research SiteInglewoodCalifornia90301-
Research SiteNorthridgeCalifornia91325-
Research SitePomonaCalifornia91767-
Research SiteBoca RatonFlorida33434-
Research SiteHialeahFlorida33012-
Research SiteJacksonvilleFlorida32216-
Research SiteMiamiFlorida33122-
Research SiteMiamiFlorida33165-
Research SiteMiamiFlorida33173-
Research SiteMiamiFlorida33174-
Research SiteOcalaFlorida34474-
Research SitePort OrangeFlorida32127-
Research SiteTamaracFlorida33321-
Research SiteChicagoIllinois60621-
Research SitePotomacMaryland20854-
Research SiteNew BedfordMassachusetts02740-
Research SiteNew WindsorNew York12553-
Research SiteBeavercreekOhio45431-
Research SiteHorshamPennsylvania19044-
Research SiteSpartanburgSouth Carolina29303-
Research SiteAustinTexas78704-
Research SiteDallasTexas75230-
Research SiteEl PasoTexas79905-
Research SiteHurstTexas76054-
Research SiteMesquiteTexas75149-
Research SiteParisTexas75462-

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By research site
Research Site· Inglewood, CAResearch Site· Northridge, CAResearch Site· Pomona, CAResearch Site· Boca Raton, FLResearch Site· Hialeah, FLResearch Site· Jacksonville, FL

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