The Effects of Cannabidiol on the Driving Performance of Healthy Adults by Dose and Sex

Conditions

• Cannabidiol Effects
• Driving Performance

Eligibility Criteria

Sex

ALL

Age

18 Years - 30 Years

Healthy Volunteers

Accepted

Interventions

• Cannabidiol (CBD) Oil 300mg — DRUG
  Cannabidiol (CBD) Oil 300mg, 1 dose
• Cannabidiol (CBD) Oil 150mg — DRUG
  Cannabidiol (CBD) Oil 150mg, 1 dose
• Placebo Oil — DRUG
  Placebo Oil, 1 dose

Study Details

The objectives/purpose of this study are to comprehensively investigate the effects of non-prescription CBD on driving performance, drowsiness, sedation, and cognitive function in a large sample of healthy adults aged 18-30 years, with additional characterization of effects by dose and by sex, using a rigorous RCT design which will naturally mitigate confounding factors.

Key Dates

Start date

Jun 30, 2025

Status verified

Oct 2025

Primary completion

Dec 31, 2028

Completion

May 1, 2029

Study Design

Enrollment

300 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Active Comparator: Cannabidiol (CBD) Oil 300mg
  Cannabidiol (CBD) Oil, 300mg, 1 dose, 120 minutes prior to testing. After consumption of the respective treatment drug, the participant will be given a standardized meal and wait for 120 minutes to allow for drug absorption and for CBD to begin taking effect; this time frame was chosen based on the pharmacokinetics of CBD along with the consideration of participant burden (max absorption 2-5 hours; average half-life 17 hours).
• Active Comparator: Cannabidiol (CBD) Oil 150mg
  Cannabidiol (CBD) Oil, 150mg, 1 dose, 120 minutes prior to testing. After consumption of the respective treatment drug, the participant will be given a standardized meal and wait for 120 minutes to allow for drug absorption and for CBD to begin taking effect; this time frame was chosen based on the pharmacokinetics of CBD along with the consideration of participant burden (max absorption 2-5 hours; average half-life 17 hours).
• Placebo Comparator: Placebo Oil
  Placebo Oil 1 dose 120 minutes prior to testing. After consumption of the respective treatment drug/placebo, the participant will be given a standardized meal and wait for 120 minutes to allow for drug absorption and for CBD to begin taking effect; this time frame was chosen based on the pharmacokinetics of CBD along with the consideration of participant burden (max absorption 2-5 hours; average half-life 17 hours).

Primary Outcome Measure

Mean standard deviation of lateral position [ Time Frame: 150 minutes post intervention ]

Central Contacts

• Toni M Rudisill, PhD
  3042930687
  [email protected]

Locations (1)

Find similar trials in Morgantown, WV

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