Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Conditions

• Liver Cancer Adult
• Liver Regeneration

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• carbon monoxide measurement via smokerlyzer — OTHER
  participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection

Study Details

the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.

Key Dates

Start date

Nov 21, 2025

Status verified

Nov 2024

Primary completion

Jan 1, 2039

Completion

Jan 1, 2039

Study Design

Enrollment

125 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: all participants
  all participants will provide breath samples to detect carbon monoxide levels

Primary Outcome Measure

correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration [ Time Frame: measurements will be taken pre, then 4 hours and 24 hours post resection ]

Central Contacts

• Jamie Ketas
  2018943418
  [email protected]
• Raquel Molina
  [email protected]

Locations (1)

Find similar trials in Englewood, NJ