Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke

Part of paid clinical trials in Galveston, Texas.

Sponsor
The University of Texas Medical Branch, Galveston
Study ID
NCT06681207
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • anodal transcranial direct current stimulation (a-tDCS) — COMBINATION_PRODUCT
    Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Stroke participants in the first two groups will receive five sessions of the assigned brain stimulation combined with visuomotor stepping training over five consecutive days. Healthy adults will be randomly assignments into a-tDCS or s-tDCS groups.

Study Details

This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.

Key Dates

Start date
Apr 23, 2025
Status verified
Sep 2025
Primary completion
Aug 30, 2026
Completion
Oct 31, 2026

Study Design

Enrollment
108 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Explore the effects of brain stimulation on locomotor skill learning in stroke survivors
    To explore the trends of locomotor skill learning in three groups: stroke survivors after five sessions of anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after five sessions of sham tDCS (s-tDCS), and stroke survivors with no brain stimulation (control; CON).
  • Experimental: determine the effects of a-tDCS on the cortical excitation before and after locomotor learning
    measure changes in cortical neuronal activation before and after five sessions of locomotor skill training in healthy adults and stroke participants.
  • Experimental: To explore improvements in learning capacity between healthy adults and stroke participants.
    Compare stimulation-induced improvements in learning capacity between three groups: stroke group, healthy young group, and healthy older group.
  • Experimental: To explore the trends of functional improvements after five tDCS session in stroke survivors
    Compare functional improvements (gait performance, balance, motor and cognitive function) between healthy adults and stroke participants after five sessions of brain stimulation.

Primary Outcome Measure

Mean change from baseline in stepping motor control after five sessions of brain stimulation combined with visuomotor stepping learning [ Time Frame: Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Physical Therapy, University of Texas Medical BranchGalvestonTexas77555
Shih-Chiao Tseng, PT, PhD
[email protected]
409-772-9555

Find similar trials in Galveston, TX

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Physical Therapy, University of Texas Medical Branch· Galveston, TX

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