Greater Houston Area Pediatric Bipolar Registry

Conditions

• Pediatric Bipolar Disorder

Eligibility Criteria

Sex

ALL

Age

6 Years - 17 Years

Healthy Volunteers

Accepted

Study Details

The purpose of this study is to perform a comprehensive research assessment of children and adolescents who meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for Bipolar Disorder (BD) , offspring of a parent with BD, and healthy controls (HC), to obtain blood samples and saliva samples from each subject to allow the evaluation for BD biomarkers and genetic information, to notify participants about future research studies they may qualify for , to recommend follow-up with an outpatient provider if needed and to use magnetic resonance imaging (MRI) (structural MRI and diffusion tensor imaging) to investigate brain structures and relevant pathways associated with mood and behavioral regulation, conversion from softer forms of the BD spectrum (BD-NOS) to harder forms (BD-I and BD-II) and possible early identification.

Key Dates

Start date

Dec 6, 2022

Status verified

Feb 2026

Primary completion

Dec 6, 2027

Completion

Dec 6, 2046

Study Design

Enrollment

1,000 participants (estimated)

Arms

• Arm: Bipolar Patients
• Arm: Offspring of Bipolar Parents
• Arm: Healthy Control Subjects

Primary Outcome Measure

Positive Identification of Bipolar Disorder as Assessed by Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI Kid 7.2) (child) [ Time Frame: baseline, annually until participant turns 25 years of age ]

Central Contacts

• Jair C Soares, M.D. PhD
  (713) 486-6663
  [email protected]
• Courtney Vecera
  (713) 486-6663
  [email protected]

Locations (1)

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