The SENTRY Study: Testing Whether Changes in Platelet RNA Enhance the Early Diagnosis of Ovarian Cancer
Part of paid clinical trials in Salt Lake City, Utah.
- Sponsor
- University of Utah
- Study ID
- NCT06665945
- Status
- Recruiting
Conditions
Eligibility Criteria
- Sex
- FEMALE
- Age
- 21 Years - N/A
- Healthy Volunteers
- Accepted
Interventions
- Platelet RNA expression — DIAGNOSTIC_TESTThe SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer.
Study Details
The purpose of the SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer. Using retrospective data, the investigators have developed an approach that appears to accurately classify ovarian cancer with relatively high sensitivity and specificity. The SENTRY Study will build upon these retrospective analyses to prospectively recruit women with ovarian cancer or an ovarian mass (and healthy control women), obtain platelet RNA samples from whole blood, and perform validation analyses to test our hypothesis.
Key Dates
- Start date
- Apr 15, 2025
- Status verified
- Apr 2026
- Primary completion
- Dec 1, 2027
- Completion
- Dec 1, 2027
Study Design
- Enrollment
- 245 participants (estimated)
Arms
- Arm: Women with a Recent Diagnosis of an Ovarian or Pelvic Mass (n=215)
- Arm: Control Women without Ovarian Cancer (n=30)
Primary Outcome Measure
Early-Stage Ovarian Cancer Detection [ Time Frame: Following informed consent (study visit 1, day 1). ]
Central Contacts
- Syrenna Lisonbee801-585-0161
Locations (1)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | Theresa Werner, MD (PRINCIPAL_INVESTIGATOR) |
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