The SENTRY Study: Testing Whether Changes in Platelet RNA Enhance the Early Diagnosis of Ovarian Cancer

Part of paid clinical trials in Salt Lake City, Utah.

Sponsor
University of Utah
Study ID
NCT06665945
Status
Recruiting

Conditions

Eligibility Criteria

Sex
FEMALE
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Platelet RNA expression — DIAGNOSTIC_TEST
    The SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer.

Study Details

The purpose of the SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer. Using retrospective data, the investigators have developed an approach that appears to accurately classify ovarian cancer with relatively high sensitivity and specificity. The SENTRY Study will build upon these retrospective analyses to prospectively recruit women with ovarian cancer or an ovarian mass (and healthy control women), obtain platelet RNA samples from whole blood, and perform validation analyses to test our hypothesis.

Key Dates

Start date
Apr 15, 2025
Status verified
Apr 2026
Primary completion
Dec 1, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
245 participants (estimated)

Arms

  • Arm: Women with a Recent Diagnosis of an Ovarian or Pelvic Mass (n=215)
  • Arm: Control Women without Ovarian Cancer (n=30)

Primary Outcome Measure

Early-Stage Ovarian Cancer Detection [ Time Frame: Following informed consent (study visit 1, day 1). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Huntsman Cancer InstituteSalt Lake CityUtah84112
Kim Norman, MPH, CPH
801-581-5895
Theresa Werner, MD (PRINCIPAL_INVESTIGATOR)

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