Prostate Tissue BioBank

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Abramson Cancer Center at Penn Medicine
Study ID
NCT06659614
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Prostate cancer is also the most common cancer in men with inherited pathogenic variants in BRCA1 and BRCA2. Beyond BRCA1/2, other genes are known to increase the risk of prostate cancer, including ATM, TP53 and HOXB13. The investigators have shown that 5% of men diagnosed with prostate cancer localized to their prostate gland and up to 10-15% of patients with metastatic prostate cancer gland are carriers of an inherited gene mutation. The Prostate Tissue BioBank is a prospective study which aims to create a biorepository of prostate tissue samples from prostate biopsies and prostatectomies and matched germline DNA from pathogenic mutation carriers in addition to age-matched control samples. Our primary goal is to investigate prostate cancer development and treatment response in carriers of germline DNA repair mutations, as compared to non-carrier controls.

Key Dates

Start date
Jan 1, 2024
Status verified
Nov 2025
Primary completion
Jan 31, 2034
Completion
Jan 31, 2034

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Carriers
    Eligible subjects will have confirmed pathogenic or likely pathogenic variants in a prostate cancer risk gene, and will also be undergoing prostate needle biopsy, prostatectomy or metastatic biopsy. Study participation will request access to medical information, blood and tissue samples.
  • Arm: Controls
    Eligible subjects will be undergoing prostate needle biopsy, prostatectomy or metastatic biopsy. Study participation will request access to medical information, blood and tissue samples.

Primary Outcome Measure

Clinical and pathological data for patients with prostate tissue samples [ Time Frame: 5 years ]

Central Contacts

  • Kara N Maxwell, MD, PhD
    215-898-9698
  • Caitlin M Orr, PhD
    215-615-3004

Locations (1)

FacilityCityStateZIPSite coordinators
University of PennsylvaniaPhiladelphiaPennsylvania19104
Kara N Maxwell, MD, PhD
215-898-9698
Caitlin M Orr, PhD
215-615-3004

Find similar trials in Philadelphia, PA

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
University of Pennsylvania· Philadelphia, PA

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