Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients

Part of paid clinical trials in Baton Rouge, Louisiana.

Sponsor
Our Lady of the Lake Hospital
Study ID
NCT06659458
Status
Recruiting
Apply to this trial

Conditions

  • EGFR Exon 19 Deletion Mutation
  • Lung Cancer - Non Small Cell

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Interventions

  • blood draw — OTHER
    A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
  • Gene sequencing — OTHER
    Subjects will have their DNA sequenced within and around the EGFR gene.

Study Details

EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.

Key Dates

Start date
Jan 1, 2025
Status verified
Oct 2024
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: EGFR Positive Lung Cancer
    Subjects diagnosed with EGFR positive lung cancer
  • Arm: Healthy Subjects
    Subjects who do not have a cancer diagnosis

Primary Outcome Measure

Differences in DNA sequence of EGFR gene [ Time Frame: From enrollment to end of data analysis at 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Our Lady of the Lake Regional Medical CenterBaton RougeLouisiana70808-

Find similar trials in Baton Rouge, LA

By research site
Our Lady of the Lake Regional Medical Center· Baton Rouge, LA

Related Studies