Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study

Part of paid clinical trials in Los Angeles, California.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT06651580
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - 17 Years
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen Collection — PROCEDURE
    Undergo collection of blood, saliva, urine or stool samples
  • Quality-of-Life Assessment — OTHER
    Complete QoL assessment
  • Questionnaire Administration — OTHER
    Complete questionnaire

Study Details

This clinical trial collects blood, saliva, urine, or stool samples to help identify possible genetic mutations that may increase a person's chance at developing pancreatic cancer. Finding genetic markers among pediatric patients with acute recurrent pancreatitis and chronic pancreatitis may help identify patients who are at risk of pancreatic cancer.

Key Dates

Start date
Apr 1, 2021
Status verified
Mar 2026
Primary completion
Feb 2, 2027
Completion
Feb 2, 2027

Study Design

Enrollment
1,600 participants (estimated)

Arms

  • Arm: Observational (biospecimen collection and questionnaire)
    Patients complete QoL assessment and complete questionnaires for over 2 hours every 12 months for 4 years. Patients also undergo collection of blood and/or saliva (if blood samples are not available), urine, or stool at baseline.

Primary Outcome Measure

Characterize the pediatric population with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) [ Time Frame: Up to 4 years ]

Central Contacts

Locations (22)

FacilityCityStateZIPSite coordinators
Cedars Sinai Medical CenterLos AngelesCalifornia90048
Quin Liu
[email protected]
310-423-6082
Quin Liu (PRINCIPAL_INVESTIGATOR)
Children's Hospital Los AngelesLos AngelesCalifornia90027
Yuhua Zheng
[email protected]
323-361-4454
Yuhua Zheng (PRINCIPAL_INVESTIGATOR)
UCSF Benioff Children's Hospital OaklandOaklandCalifornia94609
Emily Perito
[email protected]
415-476-5892
Emily Perito (PRINCIPAL_INVESTIGATOR)
Stanford Cancer Institute Palo AltoPalo AltoCalifornia94304
Zachary Sellers
[email protected]
650-497-8000
Zachary Sellers (PRINCIPAL_INVESTIGATOR)
University of ColoradoDenverColorado80217-3364
Jacob Mark
[email protected]
720-777-6669
Jacob Mark (PRINCIPAL_INVESTIGATOR)
Emory University Hospital/Winship Cancer InstituteAtlantaGeorgia30322
Reuven Cohen, MD
[email protected]
404-785-5437
Reuven "Zev" Cohen (PRINCIPAL_INVESTIGATOR)
Riley Hospital for ChildrenIndianapolisIndiana46202
Brian McFerron
[email protected]
317-944-3774
Brian McFerron (PRINCIPAL_INVESTIGATOR)
University of Iowa/Holden Comprehensive Cancer CenterIowa CityIowa52242
Aliye Uc
[email protected]
319-384-6032
Aliye Uc (PRINCIPAL_INVESTIGATOR)
Ochsner Medical Center JeffersonNew OrleansLouisiana70121
Matthew Giefer, MD
[email protected]
504-842-4021
Matthew Giefer (PRINCIPAL_INVESTIGATOR)
Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimoreMaryland21287
Kenneth Ng
[email protected]
516-906-1716
Kenneth Ng (PRINCIPAL_INVESTIGATOR)
Boston Children's HospitalBostonMassachusetts02115
Amit Grover
[email protected]
617-619-4713
Amit Grover (PRINCIPAL_INVESTIGATOR)
University of Minnesota/Masonic Children's HospitalMinneapolisMinnesota55454
Elissa Downs, MD
down@[email protected]
612-624-1133
Elissa Downs (PRINCIPAL_INVESTIGATOR)
Washington University School of MedicineSt LouisMissouri63110
Mark Lowe
[email protected]
314-286-2784
Mark Lowe (PRINCIPAL_INVESTIGATOR)
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229
Maisam Abu-El-Haija
[email protected]
513-803-2123
Maisam Abu-El-Haija (PRINCIPAL_INVESTIGATOR)
Nationwide Children's HospitalColumbusOhio43205
Cheryl Gariepy
[email protected]
614-722-8406
Cheryl Gariepy (PRINCIPAL_INVESTIGATOR)
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104
Asim Maqbool
[email protected]
215-590-3247
Asim Maqbool (PRINCIPAL_INVESTIGATOR)
Children's Hospital of Pittsburgh of UPMCPittsburghPennsylvania15224
Douglas Lindblad
[email protected]
412-946-2053
Douglas Lindblad (PRINCIPAL_INVESTIGATOR)
University of Texas Southwestern/Children's Medical CenterDallasTexas75235
Megha Mehta, MD
[email protected]
972-979-2154
Megha Mehta (PRINCIPAL_INVESTIGATOR)
M D Anderson Cancer CenterHoustonTexas77030
Suresh T. Chari
[email protected]
713-501-3714
Suresh T. Chari (PRINCIPAL_INVESTIGATOR)
Texas Children's HospitalHoustonTexas77030
Douglas Fishman
[email protected]
Douglas Fishman (PRINCIPAL_INVESTIGATOR)
Children's Hospital of San AntonioSan AntonioTexas78207
Adam Noel
205-704-4515
Adam Noel (PRINCIPAL_INVESTIGATOR)
Children's Hospital of WisconsinMilwaukeeWisconsin53226
Ankur Chugh, MD
[email protected]
414-266-4843
Ankur Chugh (PRINCIPAL_INVESTIGATOR)

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