Effects of Ublituximab on Motor Functions in Multiple Sclerosis

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Georgia State University
Study ID
NCT06629428
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Multiple Sclerosis (MS) - Relapsing-remitting

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Ublituximab — DRUG
    The participants will receive 48 weeks of treatment with ublituximab.

Study Details

The purpose of this study is to test if ublituximab changes walking functions and fall risk in people with relapsing multiple sclerosis (RMS). Twenty-five qualified people with RMS will undergo a 48-week ublituximab treatment. Before, 24 weeks into, and after the treatment, their ambulatory function, disability status, and cognition will be assessed. Additionally, they will experience large-scale slip perturbations on a treadmill under the protection of a safety harness at the last assessment. The outcome measures will be compared across the assessments to examine the effects of ublituximab on improving their walking function, disability status, cognition, and the responses to the unexpected slip perturbation.

Key Dates

Start date
Nov 13, 2025
Status verified
Feb 2026
Primary completion
Jun 30, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Ublituximab
    This arm will receive a 48-week ublituximab treatment.

Primary Outcome Measure

slip-fall [ Time Frame: 48 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Atlanta Neuroscience InstituteAtlantaGeorgia30327
Joash Lazarus, MD
[email protected]
404-351-0205
Joash Lazarus, MD (PRINCIPAL_INVESTIGATOR)
Georgia State UniversityAtlantaGeorgia30303
Feng Yang, PhD
[email protected]
404-413-8357
Feng Yang, PhD (PRINCIPAL_INVESTIGATOR)

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Atlanta Neuroscience Institute· Atlanta, GAGeorgia State University· Atlanta, GA

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