Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT06627894
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression — BEHAVIORAL
    Good Days Ahead (MindStreet, Inc.)
  • Active Control — BEHAVIORAL
    Depression education, symptom monitoring, and standard depression care

Study Details

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Key Dates

Start date
Mar 13, 2025
Status verified
Oct 2025
Primary completion
Oct 30, 2029
Completion
Oct 30, 2029

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Intervention - Internet Cognitive-Behavioral Therapy (CBT) for Depression
    Participants will complete nine 45-minute sessions of an internet CBT for depression called Good Days Ahead (GDA; MindStreet, Inc.) with 20 minutes of therapist assistance per session on the phone over six months.
  • Active Comparator: Active Control - Depression Education, Symptom Monitoring, and Usual Care
    Participants will review nine 45-minute segments of depression education material on their own with 20 minutes of therapist assistance per segment on the phone over six months. They will also have access to and could receive current depression care in the targeted healthcare systems.

Primary Outcome Measure

Subjective Cognitive Decline [ Time Frame: Measured at 6-month and 12-month follow-up. ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Eskenazi HospitalIndianapolisIndiana46202
Babar Khan, MD, MS
[email protected]
317-274-9132
IU Health Methodist HospitalIndianapolisIndiana46202
Babar Khan, MD, MS
[email protected]
317-274-9132

Find similar trials in Indianapolis, IN

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Eskenazi Hospital· Indianapolis, INIU Health Methodist Hospital· Indianapolis, IN

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