A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)

Conditions

• Healthy

Eligibility Criteria

Sex

ALL

Age

19 Years - 50 Years

Healthy Volunteers

Accepted

Interventions

• Levothyroxine — DRUG
  single oral dose
• Enlicitide Decanoate — DRUG
  single oral dose

Study Details

Levothyroxine (T4) is a man-made thyroid hormone used to treat certain thyroid conditions. After taking levothyroxine, a person's body changes it to triiodothyronine (T3). The amount of levothyroxine in a person's blood must be carefully controlled to maintain proper function. Enlicitide decanoate was designed to lower the amount of cholesterol in a person's blood. Researchers want to learn about levothyroxine when taken at the same time with enlicitide decanoate. They want to: * Measure a person's blood to find out if the amount of levothyroxine in the blood is the same when levothyroxine is taken alone or with enlicitide decanoate * Learn about the safety of levothyroxine when taken alone or with enlicitide decanoate and if people tolerate it

Key Dates

Start date

Jul 8, 2024

Status verified

Sep 2024

Primary completion

Aug 19, 2024

Completion

Sep 11, 2024

Study Design

Enrollment

28 participants (actual)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Levothyroxine
  Participants will receive a single oral dose of levothyroxine.
• Experimental: Levothyroxine Plus Enlicitide Decanoate
  Participants will receive a single oral dose of levothyroxine and a single oral dose of enlicitide decanoate at the same time.

Primary Outcome Measure

Area under the Concentration-Time Curve from Time 0 to 48 hours (AUC0-48hrs) of Levothyroxine (total T4) [ Time Frame: At designated timepoints (up to approximately 48 hours postdose) ]

Locations (1)

Find similar trials in Lincoln, NE

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