A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06623396
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Breast Neoplasms
  • Diabetes Mellitus
  • Esophageal Adenocarcinoma
  • Esophageal Adenocarcinomas
  • Esophagogastric Adenocarcinoma
  • Mesothelin Positive
  • Mesothelin-Expressing Tumors
  • Peritoneal Carcinomatosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • M28z1XXPD1DNR CAR — BIOLOGICAL
    Participants with esophagastric adenocarcinoma will be treated with an intraperitoneal infusion of different doses of autologous T cells that have been genetically modified ex vivo to express the M28z1XXPD1DNR CAR. The CAR T cells will be manufactured in MSK's Center for Cell Engineering.

Study Details

Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory at Memorial Sloan Kettering to be changed (modified) to become MSLN-targeted CAR T cells, the CAR T-cell therapy that participants will receive during the study. Participant study therapy will take about 3-4 weeks.

Key Dates

Start date
Sep 30, 2024
Status verified
Feb 2026
Primary completion
Sep 30, 2028
Completion
Sep 30, 2028

Study Design

Enrollment
18 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Mesothelin-Positive Esophagogastric Adenocarcinoma with Peritoneal Carcinomatosis
    Participants will be diagnoses with Mesothelin-Positive Esophagogastric Adenocarcinoma with Peritoneal Carcinomatosis

Primary Outcome Measure

Number of treatment-emergent adverse events [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Geoffrey Ku, MD
646-888-4588
Memorial Sloan Kettering Monmouth (Limited protocol activities)MiddletownNew Jersey07748
Geoffrey Ku, MD
646-888-4588
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Geoffrey Ku, MD
646-888-4588
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)CommackNew York11725
Geoffrey Ku, MD
646-888-4588
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Geoffrey Ku, MD
646-888-4588
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Geoffrey Ku, MD
646-888-4588
Geoffrey Ku, MD (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Nassau (Limited Protocol Activities)UniondaleNew York11553
Geoffrey Ku, MD
646-888-4588

Find similar trials in Basking Ridge, NJ

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Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited protocol activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

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