Effects of E-cigarette Use on Health

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06610838
Status
Recruiting
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Conditions

  • Electronic Cigarette Use

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Health Assessments — OTHER
    Participants will complete the blood tests, questionnaires, cardiovascular tests, and pulmonary test at visits 1, 2, and 4. Non-Contrast Chest CT and cardiopulmonary treadmill (VO2 max) stress tests will occur at visits 1 and 4. Visit 3 will not include cardiovascular and pulmonary tests.

Study Details

Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however their long-term health effects are unknown. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of cardiovascular and pulmonary disease and how they are influenced by use heaviness, age, body weight, and co-use of other products. This study will produce the most informative evidence to date on how long-term ENDS use affects cardiovascular and pulmonary health.

Key Dates

Start date
Jan 6, 2025
Status verified
Dec 2025
Primary completion
Jun 30, 2029
Completion
Jun 30, 2029

Study Design

Enrollment
600 participants (estimated)

Arms

  • Arm: ENDS users
    Long-term stable users of electronic nicotine delivery systems, 21 years of age or older, who do not use combustible (conventional) cigarettes
  • Arm: Non-users
    Gender-matched control participants who do not use ENDS or combustible cigarettes

Primary Outcome Measure

Change in mean common carotid artery intima-media thickness (CCA-IMT) [ Time Frame: Baseline to 3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UW Center for Tobacco Research and InterventionMadisonWisconsin53711-

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UW Center for Tobacco Research and Intervention· Madison, WI

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