Testing the Feasibility of Computer-based Cognitive Training in Individuals with Multiple Sclerosis Living in the Community

Conditions

• Multiple Sclerosis

Eligibility Criteria

Sex

ALL

Age

19 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• Learning and memory training — BEHAVIORAL
  The experimental group will receive memory retraining exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 training sessions).
• Sham Comparator — BEHAVIORAL
  The sham comparator group will receive sham memory exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 placebo control sessions).

Study Details

Cognitive impairments are common in multiple sclerosis (MS) diagnosed both at the onset and throughout the disease course. Poor cognitive abilities have been associated with poor outcomes such as higher levels of unemployment, poor quality of life, driving difficulties among others. Learning and memory are a common cognitive deficit. This computer-based cognitive training is a 10-session treatment proven to be effective in ameliorating learning and memory in individuals with MS across 3 realms of functioning: objective cognitive performance, daily life activities and neuroimaging. Despite this strong efficacy, as well as the recent clinical application of this computer-based cognitive training across the world, recent in-person studies have highlighted that transportation to the clinic to complete treatment sessions is a significant obstacle to clinical use of this effective treatment. To address this limitation, the proposed pilot study will test the efficacy of the computer-based cognitive training administered remotely via zoom health in persons with multiple sclerosis.

Key Dates

Start date

Sep 30, 2024

Status verified

Feb 2025

Primary completion

Dec 31, 2025

Completion

Dec 31, 2025

Study Design

Enrollment

40 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Training
  Computer based cognitive training delivered remotely via Zoom Health
• Sham Comparator: sham comparator
  The sham comparator group will receive sham memory exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 placebo control sessions).

Primary Outcome Measure

California Learning Verbal Test III [ Time Frame: Primary outcome will be assessed at baseline (1 week before training start) and immediate follow-up (within 1 week after training completion) ]

Central Contacts

• Silvana L Costa Research Scientist, PhD
  973 324 8458
  [email protected]

Locations (1)

Find similar trials in East Hanover, NJ

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