The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT06606119
Status
Recruiting
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Conditions

  • Acute Blood Loss Anemia
  • Chronic Anemia
  • Critical Illness
  • Microbiome
  • Trauma
  • Trauma Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Data and tissue collection — OTHER
    Collection of bone marrow, blood, feces, medical record data, and patient response surveys.

Study Details

Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.

Key Dates

Start date
Jan 24, 2025
Status verified
Feb 2026
Primary completion
Oct 1, 2027
Completion
Oct 1, 2028

Study Design

Enrollment
275 participants (estimated)

Arms

  • Arm: Major Trauma Injury
    Severe blunt trauma patients diagnosed with shock with a long bone or pelvic fracture requiring open reduction internal fixation or intramedullary fixation.
  • Arm: Elective Hip Replacement
    Patients undergoing elective hip replacement surgery

Primary Outcome Measure

Link the changes in HSPC and erythroid progenitor cell fate and function with sympathetic stress-induced changes establishing brain-bone marrow communication following trauma. [ Time Frame: 3 years ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
UF Academic Research BuildingGainesvilleFlorida32610
Kolenkode B Kannan, PhD
[email protected]
352-273-8455
Alicia Mohr, MD
[email protected]
352-273-5670
UF Health at Shands HospitalGainesvilleFlorida32610
Ruth Davis, BSN
[email protected]
352-273-8759
Jennifer Lanz, MSN
352-273-5497
Alicia Mohr, MD (PRINCIPAL_INVESTIGATOR)
UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UFGainesvilleFlorida32610
Alicia L Mohr, MD (PRINCIPAL_INVESTIGATOR)

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By research site
UF Academic Research Building· Gainesville, FLUF Health at Shands Hospital· Gainesville, FLUF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF· Gainesville, FL

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