Neuromodulation of Brain and Emotional Responses to Psychological Stress

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT06603064
Status
Recruiting
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Conditions

  • Anxiety
  • Healthy

Eligibility Criteria

Sex
ALL
Age
30 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Active continuous theta burst stimulation — DEVICE
    This intervention involves an active form of continuous theta burst stimulation (cTBS) that will be targeted to the dorsal anterior cingulate cortex based on neural navigation software. cTBS will be delivered in one session, lasting a few minutes, before participants complete additional testing.
  • Sham continuous theta burst stimulation — DEVICE
    This intervention involves an sham form of continuous theta burst stimulation (cTBS) that will be targeted to the dorsal anterior cingulate cortex based on neural navigation software. cTBS will be delivered in one session, lasting a few minutes, before participants complete additional testing.

Study Details

Investigators are conducting this study to test if temporarily and non-invasively stimulating the brain will affect the emotional response to stress in healthy participants. Participants will perform a series of tasks while completing an MRI scan. After this, participants will be randomized to undergo transcranial magnetic stimulation (TMS) at two visits, undergoing active stimulation at one visit and undergoing 'sham' stimulation at another visit. Immediately following both stimulation sessions, participants will repeat the tasks during MRI scanning.

Key Dates

Start date
Apr 9, 2025
Status verified
May 2026
Primary completion
Jul 31, 2028
Completion
Jul 31, 2029

Study Design

Enrollment
55 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active then Sham
    In this arm, participants will first undergo active theta burst stimulation (cTBS) at the first visit and then undergo sham cTBS in the second visit.
  • Experimental: Sham then Active
    In this arm, participants will first undergo sham theta burst stimulation (cTBS) at the first visit and then undergo active cTBS in the second visit.

Primary Outcome Measure

Dorsal anterior cingulate cortex activation to stress [ Time Frame: 30-60 mins post-stimulation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Pittsburgh Medical CenterPittsburghPennsylvania15213
Jacob White
[email protected]
412-290-1097
Natasha Brinkley
[email protected]
412-551-9163
Thomas E Kraynak, PhD (PRINCIPAL_INVESTIGATOR)

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