Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT06575881
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias. The investigators aim to study: 1. the prevalence and mechanism of inducible ventricular tachycardia 2. pace-mapping to define the site of origin of ventricular arrhythmias 3. voltage mapping to define low voltage scar substrate in the basal LV to determine the risk of development of ventricular arrhythmias in patients with genetic forms of cardiomyopathy. Participants will undergo cardiac MRI before their scheduled procedure and voltage mapping during their scheduled procedure as part of data collection.

Key Dates

Start date
Dec 13, 2023
Status verified
Apr 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2029

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: TTN-positive
    Patients with a pathogenic or likely pathogenic variant in TTN on clinical genetic testing.
  • Arm: Gene-positive
    Patients with a pathogenic or likely pathogenic variant in a gene other than TTN on clinical genetic testing.
  • Arm: Gene-negative
    Patients without a pathogenic or likely pathogenic variant in a cardiomyopathy or arrhythmia gene on clinical genetic testing.

Primary Outcome Measure

Ventricular Tachycardia Inducibility [ Time Frame: During procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37232-

Find similar trials in Nashville, TN

By condition
Atrial fibrillation
By specialty
CardiologyHeart disease
By research site
Vanderbilt University Medical Center· Nashville, TN

Related Studies