Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet

Part of paid clinical trials in Sacramento, California.

Sponsor
University of California, Davis
Study ID
NCT06574178
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Dietary Counseling — BEHAVIORAL
    A Registered Dietitian or Nutritionist will provide nutrition education either in person, over the phone, or via Zoom. The behavioral program will use cognitive-behavioral techniques to foster adherence to diet prescriptions and to build a supportive environment for the participant.

Study Details

Psoriasis is a chronic inflammatory disease that affects the skin and joints in 2-3 % of people in the United States. This inflammation of the skin, joints, and blood vessels in patients with psoriasis has been measured by older PET Scan technology but with limitations. With the new EXPLORER PET scanner technology, the investigators are testing to see if the EXPLORER is better than previous PET scanners and improve our ability to assess inflammation in patients. Also, it is known that the typical Western Diet - high in saturated fats, added sugars, and low in fiber - contributes to obesity and inflammation worldwide. There is evidence in animals that these signs of inflammation are reversible within 4 weeks when changed to a more balanced diet. Thus, this study aims to assess whether there are detectable decreases in inflammation of the skin and body of psoriasis patients who usually eat a Western Diet on an EXPLORER PET scan following 6 weeks of a more balanced diet.

Key Dates

Start date
Jan 1, 2025
Status verified
Feb 2026
Primary completion
Jun 1, 2026
Completion
Sep 1, 2026

Study Design

Enrollment
5 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Dietary Intervention
    Participants will receive breakfast, lunch, and dinner in the form of fully cooked, ready-to-heat standardized meals for 6 weeks that are prepared by a commercial kitchen.

Primary Outcome Measure

Inflammation in PET/CT scan [ Time Frame: in Week 0 and Week 6 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Davis - Dermatology DepartmentSacramentoCalifornia95816
Salsala Nasim, BS
[email protected]
916-551-2636
Samuel T Hwang, MD, PhD
[email protected]
916-551-2610
Samuel T Hwang, MD, PhD (PRINCIPAL_INVESTIGATOR)
Francene Steinberg, RD, PhD (PRINCIPAL_INVESTIGATOR)
Abhijit J Chaudhari, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Sacramento, CA

By condition
Psoriasis
By specialty
DermatologyRheumatologyAutoimmune disease
By research site
University of California, Davis - Dermatology Department· Sacramento, CA

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