Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?

Part of paid clinical trials in Fort Sam Houston, Texas.

Sponsor
Brooke Army Medical Center
Study ID
NCT06544525
Status
Recruiting
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Conditions

  • Low Back Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 64 Years
Healthy Volunteers
Not accepted

Interventions

  • Physical therapy — OTHER
    The intervention will be physical therapy standard of care.

Study Details

Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia. In subjects with normal function of the descending pain pathway, the net-effect during CPM testing is anti-nociceptive, or inhibition of the ascending pain pathway. In those with impaired descending pain pathway function, the response to CPM testing is pro-nociceptive, indicating that the body is unable to inhibit the pain signal, or may even amplify it. There is literature that supports the presence of impaired CPM, and therefore impaired descending pain pathway function, in numerus chronic pain conditions, including low back pain. Impaired descending pain pathway function may be contributing to this chronic pain presentation. This study will give us information on whether a typical physical therapy plan of care is able to improve impaired CPM, and if CPM values are predictive of improvement in physical therapy.

Key Dates

Start date
Sep 19, 2024
Status verified
Apr 2025
Primary completion
Jul 31, 2025
Completion
Jul 31, 2025

Study Design

Enrollment
57 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: chronic low back pain
    Age 18-64 years with low back pain duration greater than 3 months.

Primary Outcome Measure

Modified Oswestry Disability Index [ Time Frame: From enrollment until end of study at 6 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brooke Army Medical CenterFort Sam HoustonTexas78234-

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Brooke Army Medical Center· Fort Sam Houston, TX

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