Predicting Mortality in Kidney Transplant Recipients

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Paris Translational Research Center for Organ Transplantation
Study ID
NCT06531967
Status
Enrolling By Invitation

Conditions

  • Death

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • No intervention — OTHER
    No intervention

Study Details

Accurately predicting kidney recipient risk of death has a crucial interest because of the organ shortage, the need to optimize allograft allocation by identifying high-risk patients who may not benefit from a transplant and improve the clinical decision-making after transplant to ensure that each patient survives as long as possible. However, according to a literature review the investigators performed, studies attempting to develop a kidney recipient death prediction model suffer from many shortcomings, including the lack of key risk factors, use of biased registry data, small sample size, lack of external validation in different countries and subpopulations, and short follow-up. The present study thus aimed to address these limitations and develop a robust, generalizable kidney recipient death prediction model.

Key Dates

Start date
Jan 1, 2004
Status verified
Jul 2024
Primary completion
Jun 1, 2024
Completion
Aug 1, 2024

Study Design

Enrollment
13,000 participants (estimated)

Arms

  • Arm: Necker hospital from Paris, France
    Kidney recipients from Necker hospital
  • Arm: Saint-Louis hospital from Paris, France
    Kidney recipients from Saint-Louis hospital
  • Arm: Bichat hospital from Paris, France
    Kidney recipients from Bichat hospital
  • Arm: Bretonneau hospital from Tours, France
    Kidney recipients from Bretonneau hospital
  • Arm: Toulouse hospital, France
    Kidney recipients from Toulouse hospital
  • Arm: KU Leuven, Belgium
    Kidney recipients from KU Leuven
  • Arm: Liege hospital from Belgium
    Kidney recipients from Liege hospital
  • Arm: Leiden University Medical Center from the Netherlands
    Kidney recipients from Leiden University Medical Center
  • Arm: Hospital of the University of Pennsylvania from Philadelphia, US
    Kidney recipients from Hospital of the University of Pennsylvania
  • Arm: Mayo Clinic from Phoenix, US
    Kidney recipients from Mayo Clinic
  • Arm: UCSF database
    Kidney recipients data from real-world UCSF database
  • Arm: AP-HP database
    Kidney recipients data from real-world AP-HP database

Primary Outcome Measure

Patient death [ Time Frame: Up to 10 years after kidney transplantation ]

Locations (3)

FacilityCityStateZIPSite coordinators
Department of Medicine, Mayo ClinicPhoenixArizona85054-
Bakar Computational Health Sciences Institute, University of CaliforniaSan FranciscoCalifornia94158-
Penn Transplant Institute, Hospital of the University of PennsylvaniaPhiladelphiaPennsylvania19104-

Find similar trials in Phoenix, AZ

By research site
Department of Medicine, Mayo Clinic· Phoenix, AZBakar Computational Health Sciences Institute, University of California· San Francisco, CAPenn Transplant Institute, Hospital of the University of Pennsylvania· Philadelphia, PA

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