Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
AstraZeneca
Study ID
NCT06526793
Phase
PHASE2
Status
Recruiting
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Conditions

  • B-cell Non-Hodgkin Lymphoma
  • Follicular Lymphoma (FL)
  • Large B-Cell Lymphoma (LBCL)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Surovatamig — DRUG
    Investigational Product administered via intravenous infusion.

Study Details

This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of Surovatamig (AZD0486) monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) who have received at least two prior lines of therapies. The study has 2 Modules: Module 1 for FL and Module 2 for LBCL.

Key Dates

Start date
Nov 27, 2024
Status verified
Feb 2026
Primary completion
Mar 10, 2027
Completion
Jun 14, 2029

Study Design

Enrollment
240 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Module 1: Surovatamig Monotherapy in Participants with Relapsed or Refractory Follicular Lymphoma
    In Module 1, the efficacy and safety of surovatamig at the RP2D will be evaluated in R/R FL. Surovatamig will be administered as intravenous infusion.
  • Experimental: Module 2: Surovatamig Monotherapy in Participants with Relapsed or Refractory LBCL
    In Module 2, the efficacy and safety of surovatamig at the RP2D will be evaluated in R/R LBCL. Surovatamig will be administered as intravenous infusion.

Primary Outcome Measure

Overall response rate (ORR) (central review) [ Time Frame: Module 1: from first dose to end of treatment or data cutoff, whichever comes first, assessed up to approximately 24 months. Module 2: from first dose to end of treatment or data cutoff, whichever comes first, assessed up to approximately 12 months. ]

Central Contacts

Locations (23)

FacilityCityStateZIPSite coordinators
Research SitePhoenixArizona85054-
Research SiteDuarteCalifornia91010-
Research SiteJacksonvilleFlorida32224-
Research SiteTampaFlorida33612-
Research SiteChicagoIllinois60637-
Research SiteIowa CityIowa52242-
Research SiteWaukeeIowa50263-
Research SiteOverland ParkKansas66204-
Research SiteRochesterMinnesota55905-
Research SiteSt LouisMissouri63110-
Research SiteNew BrunswickNew Jersey08901-
Research SiteNew YorkNew York10016-
Research SiteCharlotteNorth Carolina28204-
Research SiteColumbusOhio43210-
Research SitePortlandOregon97239-
Research SitePhiladelphiaPennsylvania19104-
Research SitePittsburghPennsylvania15232-
Research SitePittsburghPennsylvania15232-
Research SiteNashvilleTennessee37203-
Research SiteAustinTexas78704-
Research SiteHoustonTexas77030-
Research SiteSan AntonioTexas78229-
Research SiteMilwaukeeWisconsin53226-

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Research Site· Phoenix, AZResearch Site· Duarte, CAResearch Site· Jacksonville, FLResearch Site· Tampa, FLResearch Site· Chicago, ILResearch Site· Iowa City, IA

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