Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction

Part of paid clinical trials in Houston, Texas.

Sponsor
University of Houston
Study ID
NCT06523335
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
40 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Neuromuscular coordination-guided rehabilitative training — OTHER
    During training exercise, post-stroke participants will be asked to match the targets on the screen. The experimental group will match them by activating a specific set of muscle. During assessment trials, a physical therapist or occupational therapist will rate the functional level of arm impairment using FMA and ARAT.
  • Force strengthening-guided rehabilitative training — OTHER
    During training exercise, post-stroke participants will be asked to match the targets on the screen. The active comparator group will match them by generating isometric force in a desired target direction. During assessment trials, a physical therapist or occupational therapist will rate the functional level of arm impairment using FMA and ARAT.

Study Details

The purposes of this study include: 1. \- To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke. 2. \- To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.

Key Dates

Start date
Oct 1, 2024
Status verified
Apr 2026
Primary completion
Sep 1, 2029
Completion
Sep 1, 2029

Study Design

Enrollment
74 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Neuromuscular coordination-guided rehabilitative training
    Post-stroke participants will perform a center-out task by generating isometric contractions of multiple muscles to move the cursor on a screen while electromyographic (EMG) responses are recorded. Activation of each muscle (or muscle group) will be mapped to 1 of 4 directions within the multi-dimensional cursor space. We will derive the cursor position in real time using EMGs recorded from multiple arm muscles.
  • Active Comparator: Force strengthening-guided rehabilitative training
    Post-stroke participants will perform a center-out task by generating isometric force to move the cursor on a screen. Participants will generate isometric force, which will move their cursor on the monitor. They will be trained to match one of the four force targets on display. We will derive the cursor position in real time using three forces (Fx, Fy, and Fz) measured at the load cell.

Primary Outcome Measure

Change in Fugl-Meyer Assessment (FMA) score [ Time Frame: before any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of HoustonHoustonTexas77204
Jinsook Roh, PhD
[email protected]
713-743-2578
Manuel A Portilla-Jiménez, MS, BME
[email protected]
346-719-4921

Find similar trials in Houston, TX

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of Houston· Houston, TX

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