Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

Conditions

• Placenta Accreta Spectrum

Eligibility Criteria

Sex

FEMALE

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Conservative/Expectant Management — OTHER
  At time of caesarean section, participants will not have a hysterectomy, but will be treated clinically to preserve their uterus.

Study Details

This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be defined as leaving the placenta in the uterus after delivery of the infant. This is a single-arm single-site pilot study where all participants will be carefully monitored during a standard postpartum inpatient stay and with outpatient follow-up until the uterus is empty.

Key Dates

Start date

Apr 21, 2025

Status verified

May 2026

Primary completion

Sep 1, 2030

Completion

Dec 31, 2030

Study Design

Enrollment

15 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: Uterine preservation
  Conservative management of PAS with the inclusion of antibiotics and uterine artery embolization, followed by close monitoring.

Primary Outcome Measure

Hysterectomy rate [ Time Frame: Delivery through 1 year ]

Central Contacts

• Beth Pineles, MD Phd
  267-226-7933
  [email protected]
• Meaghan McCabe, MPH
  [email protected]

Locations (1)

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