rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression

Conditions

• Depression, Treatment Resistant

Eligibility Criteria

Sex

ALL

Age

18 Years - 70 Years

Healthy Volunteers

Not accepted

Interventions

• Transcranial magnetic stimulation — DEVICE
  rTMS delivered at 1 Hz for 1800 pulses over 30 minutes for 20 daily sessions, 5 days/week. Treatment will be directed to the ventromedial prefrontal cortex using each participant's structural MRI.

Study Details

The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression that has not responded to at least one medication trial. The main question it aims to answer are: Does TMS to the VMPFC change brain activity on functional magnetic resonance imaging (fMRI) during a negative self-referential processing task in adults with depression? Does TMS to the VMPFC affect rumination in adults with depression? Researchers will compare brain scans and rumination scores before, during, and immediately after TMS. Participants will: Undergo three functional MRI scans Undergo a course of 20 TMS treatments Respond to clinical questionnaires and complete a computer behavioral task

Key Dates

Start date

Jan 2, 2024

Status verified

Sep 2025

Primary completion

Jun 30, 2026

Completion

Jun 30, 2026

Study Design

Enrollment

20 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: Active TMS
  All participants will receive active TMS to the VMPFC for 20 sessions

Primary Outcome Measure

Functional Connectivity [ Time Frame: Before Transcranial magnetic stimulation (TMS) - immediately following TMS ]

Central Contacts

• Susan K Conroy, MD PhD
  317-963-7300
  [email protected]

Locations (1)

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