Celecoxib for ENT Pain Management

Conditions

• Parotidectomy

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Celecoxib — DRUG
  200mg every 12 hours
• Tylenol — DRUG
  650mg q6h
• Oxycodone — DRUG
  5mg every 6 hours as needed
• placebo — DRUG
  every 12 hours

Study Details

The goal of this clinical trial is to find out whether pain can be managed after an operation with celecoxib instead of oxycodone. The main question it aims to answer is if use of celecoxib plus Tylenol reduces the need for oxycodone. Researchers will compare the combination of celecoxib and Tylenol to a placebo to find out whether celecoxib works to manage pain. Participants will: * Take celecoxib, or a placebo, plus Tylenol with opioids as needed * Keep a diary of their pain between visits * Complete questionnaires

Key Dates

Start date

Feb 28, 2025

Status verified

Dec 2025

Primary completion

Sep 30, 2026

Completion

Sep 30, 2026

Study Design

Enrollment

84 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• Experimental: Celecoxib for pain management
  Participants receive celecoxib in addition to Tylenol and oxycodone
• Sham Comparator: Placebo for pain management
  Participants receive placebo in addition to Tylenol and oxycodone

Primary Outcome Measure

Number of oxycodone pills taken [ Time Frame: 7 days ]

Central Contacts

• Hayley Mann, MD
  480-272-4258
  [email protected]

Locations (1)

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