Neural Control of Gait & Navigation in ADRD

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT06501820
Status
Enrolling By Invitation

Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
65 Years - 89 Years
Healthy Volunteers
Accepted

Interventions

  • Transcranial direct current stimulation — DEVICE
    2mA transcranial direct current stimulation, applied bilaterally on the scalp, over the brain vestibular cortex

Study Details

Brain network segregation, or independent functioning, declines with age and is associated with slower walking speed. Here, the investigators will determine the extent to which brain vestibular network segregation can be altered with bilateral vestibular cortical transcranial direct current stimulation (tDCS) in older adults with subjective cognitive decline. Participants will be randomly assigned to an active or sham stimulation condition. They will receive three, 20-minute sessions of tDCS while they are walking and performing cognitive tasks. MRI of the brain will be acquired before and after these three sessions.

Key Dates

Start date
Nov 13, 2025
Status verified
Nov 2025
Primary completion
May 1, 2029
Completion
May 1, 2030

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Sham Comparator: Sham stimulation
    The tDCS electrodes are applied and the current ramps up and then down, resulting in a very effective sham condition.
  • Experimental: Active stimulation
    Transcranial direct current stimulation, bilateral, 2 mA, applied to the vestibular cortex.

Primary Outcome Measure

Vestibular network segregation score, measured with functional MRI [ Time Frame: Pre-intervention, within 1 week post-intervention ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32611-

Find similar trials in Gainesville, FL

By research site
University of Florida· Gainesville, FL

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