Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

Part of paid clinical trials in Portsmouth, Virginia.

Sponsor
United States Naval Medical Center, Portsmouth
Study ID
NCT06488001
Phase
PHASE2
Status
Recruiting
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Conditions

  • Postoperative Nausea and Vomiting

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 79 Years
Healthy Volunteers
Accepted

Interventions

  • pantoprazole — DRUG
    Pantoprazole 40mg given the night before surgery, 2 hours prior to surgery, and the evening after surgery.
  • Placebo — DRUG
    Placebo given the night before surgery, 2 hours prior to surgery, and the evening after surgery.

Study Details

The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.

Key Dates

Start date
Aug 26, 2022
Status verified
May 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
132 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Placebo Comparator: Placebo
    This arm receives the placebo drug. This medication is taken the night before, 2 hours before surgery, and the night after surgery.
  • Active Comparator: Active
    This arm receives the pantoprazole 40mg tablet. This medication is taken the night before, 2 hours before surgery, and the night after surgery.

Primary Outcome Measure

Postoperative Nausea and Vomiting [ Time Frame: From enrollment until their postoperative visit at 6 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Naval Medical Center PortsmouthPortsmouthVirginia23708
Casey Timmerman, DO
[email protected]
757-953-7767
Casey Timmerman, DO (PRINCIPAL_INVESTIGATOR)

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By research site
Naval Medical Center Portsmouth· Portsmouth, VA

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